Critical appraisal of a pharmacoeconomic study

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  1. What is the perspective of the study? (For example, patient, provider, payer, society)
  2. What type of study is it? (For example, CMA, CEA, CBA, CUA. Is this the best type of study design for the question being posed?)
  3.  Were the competing treatment alternatives described and compared?
  4.  Were the relevant costs and consequences for each alternative properly identified?
  5. Were the relevant costs and consequences for each alternative properly measured?
  6.  Were the relevant costs and consequences for each alternative properly valued?
  7.  Were the instruments used to measure patient preferences or quality of life validated? (For example, How have these instruments been used in the past? Do experts in the field consider them to be valid?)
  8. What are the assumptions and limitations of the study? (All assumptions and limitations should be clearly stated.
  9. Were costs and consequences adjusted for different time periods (i.e., discounting)?
  10. Was a sensitivity analysis performed? (If the analysis is built on certain assumptions, then the robustness of these assumptions should be tested by changing the assumptions to see whether the results are the same.)

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