In a man who is heterozygous at two different loci A and B

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1. In a man who is heterozygous at two different loci A and B, what percentage of his sperm will have the following haploid genotypes? a) AB b) bA 2. In a family with 6 children, how many different permutations of birth order satisfy the scenario of having four boys and two girls? 3. A couple knows they are both carriers of an allele for the recessive Parkinson’s Disease. They would like to have 4 children and want to know the likelihood that none of their children will have Parkinson’s in later life. What is the probability of this outcome? 4. You do not have Parkinson’s Disease, but your father has it. There is no history of Parkinson’s Disease in your mother’s family. What is the probability that you will pass on the Parkinson’s allele (p) to your offspring? What assumption do you make about your mother in order to calculate this probability? 5. Now consider this scenario. Your father (now deceased) did not get Parkinson’s disease in his old age, but his brother (your uncle) did. Now what is the probability that you are a carrier? 6. Same scenario as Q5, but now what is the probability that your child will be a carrier?


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